What is CagriSema?
CagriSema is a dual-incretin therapy combining Semaglutide (a GLP-1 receptor agonist) and Cagrilintide (an amylin analogue). It is used for effective weight management and appetite regulation. It is administered once weekly via subcutaneous injection using this prefilled multidose pen.
What GLP is it?
CagriSema combines two hormone analogues:
– GLP-1 (Semaglutide): Enhances insulin secretion, delays gastric emptying, reduces appetite.
– Amylin Receptor Agonist (Cagrilintide): Promotes satiety, reduces food intake, complements GLP-1 activity.
Together, they act synergistically to improve metabolic regulation and weight control.
Anabolic?
CagriSema is not an anabolic agent. While it does not directly build muscle mass, it supports metabolic efficiency and fat reduction, which may enhance body composition when combined with proper exercise and nutrition.
Active Ingredients
Each prefilled multidose pen contains:
– 6 mg Semaglutide
– 6 mg Cagrilintide
– Total: 12 mg over 240 clicks (0.05 mg per click)
Benefits
– Dual-action on GLP-1 and amylin receptors for enhanced weight loss
– Strong appetite suppression and improved satiety
– Improved blood sugar regulation
– Once-weekly convenience
– May support lean mass retention during fat loss
Instructions for Use
Follow these steps to use your CagriSema pen safely and effectively:
1. Prepare Your Pen
– Verify the label, inspect solution, and remove the cap.
2. Attach the Needle
– Use a sterile needle. Attach by turning clockwise, then remove both caps.
3. Prime Your Pen
– Turn selector to 1 click. Press to check for liquid flow. Repeat if needed.
4. Select Your Clicks
– Start with 20 clicks and gradually increase based on tolerance:
Weeks 1–4: 5 clicks/week
Weeks 5–8: 10 clicks/week
Weeks 9–12: 20 clicks/week
Weeks 13–14: 34 clicks/week
5. Injecting Your Dose
– Use abdomen, thigh, or arm. Clean site, inject at 90°, press button, hold 6 seconds.
6. After Injection
– Dispose of needle safely. Cap pen for future use.
Warnings
Do not use if allergic to any ingredients. Not recommended during pregnancy or breastfeeding. Use with caution in patients with thyroid issues, kidney problems, or gastroparesis. Common side effects include nausea and digestive discomfort.
Storage
Store unopened pens in a refrigerator at 2°C to 8°C. Do not freeze. Once opened, keep below 30°C and use within 28 days. Protect from direct sunlight.
Additional Information
Administer once weekly on the same day. If a dose is missed, take it within 4 days. After that, skip the missed dose and resume on your next scheduled day. Dispose of all sharps properly. Consult your healthcare provider with any concerns.